Endocrine Abstracts

Introduction: The incidence of end stage renal failure (ESRF) secondary to diabetes mellitus (DM) is increasing worldwide. Renal replacement therapy, which if started early improves prognosis, is a common treatment for ESRF.Objective: To determine the waiting time and factors that influence the provision of emergency renal replacement therapy in patients with ESRF secondary to DM admitted to the emergency room of a tertiary care hospital.<p class="ab...

Dynamic pituitary testing is a time consuming and high cost investigation. For effective use of this procedure a close audit of the effectiveness and outcome of testing is required. At UCH we have developed a streamlined nurse led service with medical supervision and we now present an audit of 1 year of testing.Forty-one patients underwent pituitary function testing for growth hormone (GH) and ACTH during 2006. Referral source was from the endocrine team...

Backgroud: Primary hyperparathyroidism is the most common cause of hypercalcemia, which is associated with an increased frequency of hypertension. However, there are no data on the prevalence of primary hyperparathyroidism in patients who present with hypertension.Clinical case: We present the case of a 40-year-old woman with a history of hypertension for ten years. In 2017 she was referred for evaluation of hypercalcemia. The patient denied any symptoms...

BackgroundIt is known that the thyroid gland is sensitive to the damaging effects of irradiation, and patients who have received radiotherapy for tumor treatment require regular thyroid screening subsequently. A few cases of thyroid cancer after receiving 131I-metaiodobenzylguanidine (MIBG) therapy in the treatment of neuroblastoma in childhood have been described (HM van Santen et al 2012; SC Clement et al, 2013). Here, we report the two cases of papill...

Introduction and Objective: Thyroid cancer (TC) is the most common endocrine tumor with a growing incidence worldwide. However, diagnostics using ultrasound research methods do not allow to unambiguously determine the type of thyroid lesion and make a precise diagnosis in early stages. The results of recent studies indicate the metabolic changes occurring in cancer cells. Various molecular biomarkers and indices (TYG, TYG-BMI) may indicate the onset of development and progress...

Pituitary adenomas constitute the third most common intracranial neoplasm. Adenoma cells either express no hormone (null cell adenoma) or hormones of different cell lineage. About 1% of pituitary adenomas shows a plurihormonal expression pattern, which may either be attributed to one cell lineage or rarely to different cell lineages. In addition, the development of separate pituitary adenomas may be observed in 0.5–1.5% of surgical specimens and in up to 10% of autopsy ca...

We report on a case of a 63-year-old male patient with a history of metastatic DTC, with both lung and bone metastases and an additional paravertebral mass. The patient presented with enlargement of the left thyroid lobe. FNA was positive for malignancy and subsequent CTs were negative for distant metastases, whereas laboratory tests showed elevated thyroglobulin (Tg>500 ng/ml). The patient underwent total thyroidectomy and the pathology report revealed a multifocal, folli...

BackgroundCurrently, serious complications of secondary hyperparathyroidism (sHPT) are rare due to early diagnosis and more effective treatments. These complications include osteitis fibrosa cystica, which is characterized by bone resorption and brown tumors. Depending on the location, they can cause pain or compressive symptoms.Case reportWe report a case of a 41-year-old black woman with a past medical hist...

Background: Parathyroid Carcinoma (PC) is a very rare endocrine malignancy. Unlike Parathyroid Adenoma (PA) and Parathyroid Hyperplasia which represents 80% and 15-20% cases of primary hyperparathyroidism (PHPT) respectively, PC only constitutes 1-2% of cases. Herein we present a clinical case of PC following a low-impact trauma.Clinical case: A 50-year-old Bulgarian female presented with a pathological mid-shaft fracture of her right femur following a t...

Background: Pituitary adenomas (PAs)/Pituitary Neuroendocrine Tumors (PitNETs) are a complex and heterogeneous group of lesions. Genetic and epigenetic studies have been performed to identify predictors of treatment outcome.Study aim: To profile clinically non-aggressive (NA) and aggressive (A) PAs/PitNETs, and carcinomas for somatic mutations and epigenetic alterations of genes involved in cell proliferation/differentiation, miRNA/lncRNA-post-transcript...